No, it's not generally adviseable to delete CAB files. If you're running that low 
on space, you should add a second hard disk. There's other folders and junk you can 
get rid of to free up some space. 

If you install Hotfixes, you'll have a lot of folders in this Windows directory. 
If you've no intention of uninstalling any of those Hotfixes/updates, you can safely 
delete these: $NtUninstall KBxxxxxx$ (They'll likely be in blue) They take 
up a lot of space. First, you need to unhide all files and folders. 

It's usually advised NOT to delete their associated folders in this directory:
C:\WINDOWS\$hf_mig$.

Dealing with Unwanted Spyware and Parasites

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